Zytiga Makes Lupron Redundant

Clinical trials are ongoing to evaluate the effects of Zytiga as first line therapy when given 3 weekely Lupron injections as well. Lupron is an LHRH agonist which lowers testosterone levels, whilst Zytiga is able to completely block testosterone production throughout the body, which makes the use of Lupron redundant. So Zytiga blocks all testosterone production anyway and the hormone injection is superfluous. Why do these doctors continue to inject hormones when they know that they are doing nothing more to control the disease. Surely the continued use of Lupron whilst on Zytiga is questionable and there is no evidence that continued use of Lupron with Zytiga is beneficial to the patient. The best neoadjuvant use of Zytiga is therefore as a single agent without Lupron perhaps combined with a low dose of a corticosteroid such as prednisone to offset hyopkalemic side effects.