BEZ-235 Zytiga Combo

BEZ-235 is a potent inhibitor of PI3K and mTOR which are involved in drug resistance. Continued AR signalling in prostate cancer is mediated by the PI3K/Akt/mTOR pathway and so inhibition of members of this pathway interferes with cell survival signalling and inhibitors of PI3K such as salvestrols causes tumours to undergo apoptosis and cell death. Zytiga resistance is believed to be mediated by PI3K signalling and various inhibitors of this pathway are under investigation in combination with Zytiga. The combination of BEZ-235 with Zytiga is being clinically trialed and should overcome drug resistance and may offer additional anticancer activity.

Molecular structure of BEZ-235 shows it is an imidazoquinoline.