Should Xtandi Be Taken at a Lower Dose ?

The incidence of seizure from Xtandi has increased to 7 patients in the ongoing clinical trials in 800 men at a dose of 160 mg daily. Xtandi has a half life in the human body of 7 days and so its concentration will increase in the body upon daily dosing reaching potentially fatal levels in the body. The level of the drug in the human body increases daily and after 30 days the onset of seizures is observed.

Surely with a half life of 7 days this drug should be taken on a once weekly basis instead of once daily to allow the body time to metabolise it. This would reduce the cost of Xtandi dramaticaly from $ 7,450 per month to around $ 1,000 per month which makes economic sense. Weekly Xtandi dosing takes into account the long half-life of this drug and would prevent drug accumulation and so may circumvent the risk of heart seizure.