Tuesday 1 May 2012

Molecular Graphics of Zytiga Mechanism



Above diagram shows the mechanism of the CYP17 enzyme worked out by Prof Gerry Potter in 1990. Below are modern molecular graphics of the inner workings of the CYP17 enzyme from an article in Nature 2012 which shows the detailed interactions of Abiraterone with CYP17 which confirmed the original hypothesis for the design of Abiraterone.

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