In a clinical study at the Dana Farber Institute in the USA, researchers used half the dose of prednisone (a steroid) standardly given with abiraterone acetate. This lower dose (5 mg), it is hoped, would reduce the side effects associated with steroids while maintaining its benefits of protecting particular steroid imbalances associated with abiraterone. Since there were no increased side effects from abiraterone, the researchers feel that the lower dose of prednisone (5mg daily) is adequate for most patients.
"Most of the patients in this study had large tumors, high grade prostate cancers and were at high risk for cancer spread," Taplin remarks. "We're very encouraged by the results."
These results show that Zytiga can be safely taken with low dose prednisone (5 mg daily) to good effect, and that the low dose of prednisone is sufficient to prevent the side effects from Zytiga that result from corticosteroid imbalance.
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